EXTRACT

Rating

Description

A+

• Effects (or lack of effects) supported by more than two published case reports, clearly implicating or ruling out the whole herb in the causation of the adverse effect, in peer-reviewed journals with pharmacological/toxicological rationale.

A-

• Effects (or lack of effects) supported by one or two published case reports, clearly implicating or ruling out the whole herb in the causation of the adverse effect, in peer-reviewed journals.

B

• Effects (or lack of effects) supported by two or more published case reports involving whole herb, but not clearly implicating nor ruling out the herb in the causation of the adverse effect, in peer-reviewed journals
• or by documented traditional cautions.

C

• Effects (or lack of effects) supported by occasional case reports in medical journals or at regulatory agencies/poisons centres
• or by published case reports involving constituents of the herb that are known to be prominent in the action of the herb
• or by pharmacological/toxicological rationale without case reports.

D

• Effects (or lack of effects) supported by case reports involving constituents only.
• or animal studies only
• or speculation based on traditional information.

E

• Effects (or lack of effects) supported by theoretical case only.

F

• No support for effects (or lack of effects) in theory or practice.